Week 1 is officially in the books, and fantasy managers are already scrambling for answers. Injuries, breakout performances, and surprise depth chart shifts have opened the door for big-time waiver opportunities. If you want to stay ahead of your league, these are the top pickups to target heading into Week 2 of the 2025 season.

Top Targets

1. Dylan Sampson – RB, Browns (43–46% rostered)
8 catches for 64 yards in Week 1, thriving in the passing game. With Judkins nicked up, Sampson has RB2 PPR upside immediately.

2. Quentin Johnston – WR, Chargers (8.7% rostered)
Breakout game finally arrived. With Keenan Allen fading, Johnston could slide into the WR1 role quickly.

3. Michael Penix Jr. – QB, Falcons (20% rostered)
42 attempts and showed rushing ability. Volume + talent = must-stash in 1-QB, starter in Superflex.

4. Harold Fannin Jr. – TE, Browns (2.7% rostered)
7 catches, 63 yards. Already involved in heavy 2-TE sets — legit sleeper at a thin position.

Secondary Targets

• Aaron Rodgers – QB, Steelers (8.7% rostered): 4 TDs in his return. Risky O-line but upside remains.

• Isaac Guerendo – RB, 49ers (7.7%): Direct McCaffrey handcuff. High-priority stash.

• JuJu Smith-Schuster – WR, Chiefs (1%): Trusted veteran with Worthy out and Rice suspended.

• Calvin Austin III – WR, Steelers (4.4%): Got targets from Rodgers, flashed speed and playmaking.

Deep League Stashes

• Daniel Jones – QB, Colts (4.9%): 272 yds + 2 rushing TDs. Dual-threat floor is playable.

• DJ Giddens – RB, Colts (5.2%): Taylor’s backup — stash with upside.

• Kayshon Boutte – WR, Patriots (2.0%): Maye’s early go-to WR.

• Juwan Johnson – TE, Saints (3.7%): Locked-in snap share with Taysom sidelined.